RGD Reference Report - Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? - Rat Genome Database

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Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

Authors: Johansen, JS  Milman, N  Hansen, M  Garbarsch, C  Price, PA  Graudal, N 
Citation: Johansen JS, etal., Respir Med. 2005 Apr;99(4):396-402. Epub 2004 Nov 5.
RGD ID: 4892634
Pubmed: PMID:15763444   (View Abstract at PubMed)
DOI: DOI:10.1016/j.rmed.2004.09.016   (Journal Full-text)

BACKGROUND: YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity. METHODS: Serum YKL-40 was determined by radioimmunoassay in 27 patients with a histological diagnosis of pulmonal sarcoidosis. Immunohistochemical staining for YKL-40 antigen was performed in five biopsies with pulmonary sarcoid lesions. Serum YKL-40 was likewise measured in 173 healthy age-matched control subjects. RESULTS: Mononuclear cells/macrophages and giant cells in pulmonary sarcoid granulomas expressed YKL-40 protein. Serum YKL-40 was higher in patients with pulmonary sarcoidosis compared to controls (P<0.001) and 63% had elevated serum YKL-40. There was a positive correlation between serum YKL-40 and serum angiotensin converting enzyme (rho=0.55, P=0.0053). Patients with serum YKL-40>median value in the patient group had lower carbon monoxide diffusion capacity corrected for alveolar volume (DLCO/VA) than patients with serum YKL-40 the median value (P=0.015). Conclusions: Serum YKL-40 may be a novel biomarker of sarcoid disease activity and ongoing fibrosis in patients with pulmonary sarcoidosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary sarcoidosis  IEP 4892634protein:increased secretion:serum (human)RGD 
pulmonary sarcoidosis  ISOCHI3L1 (Homo sapiens)4892634; 4892634protein:increased secretion:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Chi3l1  (chitinase 3 like 1)

Genes (Mus musculus)
Chi3l1  (chitinase 3 like 1)

Genes (Homo sapiens)
CHI3L1  (chitinase 3 like 1)


Additional Information