RGD Reference Report - Plasma YKL-40 levels are elevated in patients with chronic heart failure. - Rat Genome Database

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Plasma YKL-40 levels are elevated in patients with chronic heart failure.

Authors: Rathcke, CN  Kistorp, C  Raymond, I  Hildebrandt, P  Gustafsson, F  Lip, GY  Faber, J  Vestergaard, H 
Citation: Rathcke CN, etal., Scand Cardiovasc J. 2010 Apr;44(2):92-9.
RGD ID: 4892629
Pubmed: PMID:19961288   (View Abstract at PubMed)
DOI: DOI:10.3109/14017430903402218   (Journal Full-text)

OBJECTIVES: Congestive heart failure (CHF) has been associated with elevated biomarker levels reflecting chronic low-grade inflammation. YKL-40 is a biomarker with increasing levels in patients with cardiovascular disease (CVD) of increasing severity. Furthermore, YKL-40 is associated with all-cause and cardiovascular mortality. We investigated plasma YKL-40 levels in patients with CHF and evaluated the possible predictive value with respect to overall mortality and recurrent cardiovascular outcomes. DESIGN: Plasma YKL-40 was measured in 194 CHF patients and in 117 age-matched individuals without CVD. RESULTS: Median YKL-40 levels were approximately 77% higher in patients with CHF (106 (IQR, 66-184) ng/ml vs. 60 (IQR, 42-97) ng/ml, p < 0.0001). We found a trend towards an association of YKL-40 levels with urinary albumin/creatinine ratio (UACR) (beta = 0.12, p = 0.08). YKL-40 levels were not predictive of overall mortality (p = 0.59), major cardiovascular events (p = 0.23) or events of incompensation (p = 0.56). CONCLUSIONS: Plasma YKL-40 levels are elevated in patients with CHF but show no association with other clinical or paraclinical variables. YKL-40 levels were not predictive of overall mortality or incident cardiovascular events. Most likely, elevated YKL-40 levels in CHF patients are explained by the presence of concomitant diseases but a role of YKL-40 in low-grade inflammation is not excluded.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
congestive heart failure  IEP 4892629protein:increased secretion:plasma (human)RGD 
congestive heart failure  ISOCHI3L1 (Homo sapiens)4892629; 4892629protein:increased secretion:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Chi3l1  (chitinase 3 like 1)

Genes (Mus musculus)
Chi3l1  (chitinase 3 like 1)

Genes (Homo sapiens)
CHI3L1  (chitinase 3 like 1)


Additional Information