RGD Reference Report - [Effect of glucocorticoid receptor blockade on pulmonary and renal vascular permeability in scalded rats]. - Rat Genome Database

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[Effect of glucocorticoid receptor blockade on pulmonary and renal vascular permeability in scalded rats].

Authors: Lin, H  Gong, X  Zhong, J 
Citation: Lin H, etal., Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995 Mar;11(2):103-5.
RGD ID: 4892565
Pubmed: PMID:7648494   (View Abstract at PubMed)

With glucocorticoid receptor (GR) blockade by RU38486, a competitive antagonist of GR, the change in contents of FITC labeled albumin (FITC-albumin) in pulmonary and renal tissue in scalded rats have been measured to study the changes in vascular permeability. The result showed that the contents of FITC-albumin in pulmonary and renal tissue in the scalded rats were markedly higher than those of the controls (lung: P < 0.05, kidney: P < 0.001). When the scalded rats were given GR blockade, the contents of FITC-albumin in pulmonary and renal tissue were significantly higher than those of rats with scald only (P < 0.05). The results indicated: (1) the pulmonary and renal vascular permeability in scalded rats was markedly enhanced; (2) GR blockade might aggravate the increase in vascular permeability caused by scald, so that the protective effect of glucocorticoid (GC) on vascular permeability seemed to be reversed.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)


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