RGD Reference Report - Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea. - Rat Genome Database

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Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea.

Authors: Shigemitsu, M  Nishio, K  Kusuyama, T  Itoh, S  Konno, N  Katagiri, T 
Citation: Shigemitsu M, etal., Int J Cardiol. 2007 Feb 14;115(3):354-60. Epub 2006 Jun 23.
RGD ID: 4892059
Pubmed: PMID:16806535   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ijcard.2006.03.018   (Journal Full-text)

BACKGROUND: Sleep disordered breathing has been reported to be associated with congestive heart failure (CHF). Nocturnal oxygen has been shown to abolish apnea. The aim of this study is to examine whether nocturnal oxygen reduces sympathetic nerve activity, and prevents progress of CHF. METHODS: 93 patients with left ventricular ejection fractions < 60%, were examined with overnight saturation monitoring for an oxygen desaturation index. Subjects with oxygen desaturation of 4% > or = 4/h were examined with polysomnography. Apnea-hypopnea index (AHI) was calculated as the total number of episodes of apnea and hypopnea per hour of sleep. We started nocturnal oxygen for the patients with AHI > or = 20. Urinary and plasma catecholamines concentrations, serum brain natriuretic peptide, human atrial natriuretic peptide, and endothelial nitric oxide synthase levels were measured before and after starting oxygen. RESULTS: Compared among the three groups, CHF with central sleep apnea (CHF-CSA) group had significantly higher 24-h urinary adrenaline (CHF-CSA: 4.411+/-2.940 micromol/day, CHF with obstructive sleep apnea (CHF-OSA): 2.686+/-1.084 micromol/day, CHF without apnea (CHF-N): 3.178+/-1.778 micromol/day, P<0.05). Oxygen therapy significantly decreased AHI and 4 serum BNP levels (from 91.75+/-80.35 pg/ml to 52.75+/-45.70 pg/ml, mean change=33.85 pg/ml, P=0.0208). Serum eNOS levels were lower in CHF-CSA group and CHF-OSA group than in CHF-N group (CHF-CSA: 15.89+/-10.75 pg/ml, CHF-OSA: 7.46+/-3.91 pg/ml, CHF-N: 27.33+/-14.83 pg/ml, P<0.05). CONCLUSIONS: Nocturnal oxygen may prevent progress of CHF with central sleep apnea.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
central sleep apnea  IEP 4892059associated with heart failure and protein:decreased expression:serumRGD 
central sleep apnea  ISONOS3 (Homo sapiens)4892059; 4892059associated with heart failure and protein:decreased expression:serumRGD 
obstructive sleep apnea  IEP 4892059associated with heart failure and protein:decreased expression:serumRGD 
obstructive sleep apnea  ISONOS3 (Homo sapiens)4892059; 4892059associated with heart failure and protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information