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Distribution of CTLA-4 polymorphisms in allergic asthma.

Authors: Jasek, M  Luszczek, W  Obojski, A  Winiarska, B  Halubek, K  Nowak, I  Manczak, M  Wisniewski, A  Pawlik, A  Jonkisz, A  Lebioda, A  Majorczyk, E  Dobosz, T  Kusnierczyk, P 
Citation: Jasek M, etal., Int Arch Allergy Immunol. 2006;141(3):223-9. Epub 2006 Aug 22.
Pubmed: (View Article at PubMed) PMID:16926542
DOI: Full-text: DOI:10.1159/000095292

BACKGROUND: The CTLA-4 molecule is an important negative regulator of T cell activation. It is encoded on chromosome 2q33 and found to be associated with several allergic phenotypes including asthma. However, the association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study. METHODS: By PCR-RFLP, the distribution of three single nucleotide polymorphisms (SNPs), -1147 C/T, -318 C/T, and +49 A/G, was examined in 219 Polish Caucasoid patients diagnosed with allergic asthma and in 102 ethnically matched healthy control individuals. (AT)(n) microsatellite polymorphism was also tested in the same individuals. RESULTS: No statistically significant differences in SNPs or microsatellite allele, genotype or haplotype frequencies between patients and controls were found. CONCLUSION: CTLA-4 polymorphisms do not seem to be a risk factor for allergic asthma in Poles.


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RGD Object Information
RGD ID: 4891528
Created: 2011-01-18
Species: All species
Last Modified: 2011-01-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.