RGD Reference Report - Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. - Rat Genome Database

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Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation.

Authors: Gonzalo, JA  Pan, Y  Lloyd, CM  Jia, GQ  Yu, G  Dussault, B  Powers, CA  Proudfoot, AE  Coyle, AJ  Gearing, D  Gutierrez-Ramos, JC 
Citation: Gonzalo JA, etal., J Immunol. 1999 Jul 1;163(1):403-11.
RGD ID: 4891475
Pubmed: PMID:10384142   (View Abstract at PubMed)

The cloning, expression, and function of the murine (m) homologue of human (h) monocyte-derived chemokine (MDC) is reported here. Like hMDC, mMDC is able to elicit the chemotactic migration in vitro of activated lymphocytes and monocytes. Among activated lymphocytes, Th2 cells were induced to migrate most efficiently. mMDC mRNA and protein expression is modulated during the course of an allergic reaction in the lung. Neutralization of mMDC with specific Abs in a model of lung inflammation resulted in prevention of airway hyperreactivity and significant reduction of eosinophils in the lung interstitium but not in the airway lumen. These data suggest that mMDC is essential in the transit/retention of leukocytes in the lung tissue rather than in their extravasation from the blood vessel or during their transepithelial migration into the airways. These results also highlight the relevance of factors, such as mMDC, that regulate the migration and accumulation of leukocytes within the tissue during the development of the key physiological endpoint of asthma, airway hyperreactivity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL22Humanasthma  ISOCcl22 (Mus musculus) RGD 
Ccl22Ratasthma  ISOCcl22 (Mus musculus) RGD 
Ccl22Mouseasthma  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Mus musculus)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Homo sapiens)
CCL22  (C-C motif chemokine ligand 22)


Additional Information