RGD Reference Report - Oleoyl-estrone increases adrenal corticosteroid synthesis gene expression in overweight male rats. - Rat Genome Database

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Oleoyl-estrone increases adrenal corticosteroid synthesis gene expression in overweight male rats.

Authors: Romero Mdel, M  Vila, R  Fernandez-Lopez, JA  Esteve, M  Alemany, M 
Citation: Romero Mdel M, etal., Steroids. 2010 Jan;75(1):20-6. Epub 2009 Sep 28.
RGD ID: 4891149
Pubmed: PMID:19793540   (View Abstract at PubMed)
DOI: DOI:10.1016/j.steroids.2009.09.009   (Journal Full-text)

Oleoyl-estrone (OE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of this feedback regulation. Dietary overweight male rats were given oral 10nmol/g OE gavages for ten days. A group (PF) of pair-fed to OE rats, and controls received vehicle-only gavages. OE rats lost slightly more body than PF, but had larger adrenal glands. Tissue corticosterone levels, and gene expressions for glucocorticoid-synthesizing enzymes were increased in OE versus controls and PF; thus, we assumed that adrenal growth affected essentially its cortex since OE also lowered the expression of the medullar catecholamine synthesis enzyme genes. Serum corticosterone was higher in PF than in OE and controls, but liver expression of corticosteroid-disposing steroid 5alpha-reductase was 3x larger in OE than PF and controls. Circulating glucocorticoids changed little under OE, in spite of higher adrenal gland and liver content, hinting at modulation of glucocorticoid turnover as instrumental in their purported increased activity. In conclusion, we have observed that OE considerable enhanced the expression of the genes controlling the synthesis of glucocorticoids from cholesterol in the rat and increasing the adrenal glands' corticosterone, size and cellularity, but also the liver disposal of corticosteroids, suggesting that OE increases corticosterone synthesis and degradation (i.e. serum turnover), a process not driven by limited energy availability but directly related to the administration of OE.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to estrogen  IEP 4891149oleoyl-estroneRGD 

Objects Annotated

Genes (Rattus norvegicus)
Srd5a1  (steroid 5 alpha-reductase 1)


Additional Information