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Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemia.

Authors: Cowell, RM  Xu, H  Parent, JM  Silverstein, FS 
Citation: Cowell RM, etal., J Neuroimmunol. 2006 Apr;173(1-2):155-65. Epub 2006 Mar 3.
Pubmed: (View Article at PubMed) PMID:16516309
DOI: Full-text: DOI:10.1016/j.jneuroim.2006.01.005

The chemokine macrophage inflammatory protein 1alpha (CCL3) is expressed by immune cells in the normal and injured perinatal brain. To determine whether the chemokine receptor CCR5 is a relevant target for CCL3 in the brain, we used RT-PCR and immunocytochemistry to assess changes in CCR5 expression and localization in developing normal and injured rat forebrain. CCR5 protein was expressed predominately by resting and activated microglia until 2 weeks of age. Neonatal hypoxia-ischemia increased CCR5 mRNA expression while causing CCR5 internalization, indicating receptor activation. These data implicate CCR5 in microglial recruitment and activation during brain development and after neonatal brain injury.


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RGD Object Information
RGD ID: 4890442
Created: 2010-12-20
Species: All species
Last Modified: 2010-12-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.