RGD Reference Report - Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats. - Rat Genome Database

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Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats.

Authors: Vachhrajani, KD  Chowdhury, AR 
Citation: Vachhrajani KD and Chowdhury AR, Indian J Exp Biol. 1990 Aug;28(8):746-51.
RGD ID: 4889587
Pubmed: (View Article at PubMed) PMID:2253967

Intraperitoneal administration of methylmercury chloride (MMC) and mercuric chloride (MC) to male rats in doses of 5, 10 micrograms MMC/kg or 50, 100 micrograms MC/kg for 90 days induced cellular disintegration of Leydig cells which was conspicuous on day 30 and onwards in the exposed groups. Progressive degeneration of Leydig cells and decrease in their nuclear diameter and population were associated with gradual increase in deposition of mercury. Gradual diminution of 3 beta-hydroxy-delta 5-steroid dehydrogenase activity in Leydig cells after MMC or MC treatment was correlated with different structural deformations of the cells over 90 days. Moreover, a significant decrease in serum testosterone levels by day 90 confirmed steroidogenic impairment after MMC or MC treatment.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Hsd3b1  (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)


Additional Information