RGD Reference Report - Deuterium oxide protects against myocardial injury induced by ischemia and reperfusion in rats. - Rat Genome Database

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Deuterium oxide protects against myocardial injury induced by ischemia and reperfusion in rats.

Authors: Ishikawa, Yuko  Kitagawa, Hirotoshi  Sawada, Tadashi  Seto, Tomoyoshi  Takahashi, Kan  Yamazaki, Toji 
Citation: Ishikawa Y, etal., Scand Cardiovasc J. 2019 Dec;53(6):329-336. doi: 10.1080/14017431.2019.1657939. Epub 2019 Aug 28.
RGD ID: 487982219
Pubmed: PMID:31455109   (View Abstract at PubMed)
DOI: DOI:10.1080/14017431.2019.1657939   (Journal Full-text)

Objectives. Although deuterium oxide (D2O) has preservative property on the extracted organ, whether D2O also protects the in situ myocardial injury remains unknown. Using cardiac microdialysis, local administration of D2O through dialysis probe was applied in situ rat heart. We examined the effect of the D2O on the myocardial injury induced ischemia, reperfusion, and chemical hypoxia. Methodology. We measured dialysate myoglobin levels during 30 min of coronary occlusion and reperfusion in the absence and presence of D2O. Furthermore, to confirm the effect of D2O on NaCN induced myocardial injury, we measured the dialysate myoglobin levels with local perfusion of NaCN in the absence and presence of D2O. Results. The dialysate myoglobin levels increased from 177 ± 45 ng/mL at baseline to 3030 ± 1523 ng/mL during 15-30 min of coronary occlusion and further increased to 8588 ± 1684ng/mL at 0-15 min of reperfusion. The dialysate myoglobin levels with 60 min local perfusion of NaCN increased to 1214 ± 279 ng/mL. D2O attenuated myocardial myoglobin release during 15-30 min of coronary occlusion and 0-30 min of reperfusion and 15-60 min of local perfusion of NaCN. Conclusions. D2O might have a beneficial effect of myocardium against ischemia, reperfusion and chemical hypoxia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBHumanMyocardial Reperfusion Injury treatmentISOMb (Rattus norvegicus) RGD 
MbRatMyocardial Reperfusion Injury treatmentIEP  RGD 
MbMouseMyocardial Reperfusion Injury treatmentISOMb (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mb  (myoglobin)

Genes (Mus musculus)
Mb  (myoglobin)

Genes (Homo sapiens)
MB  (myoglobin)


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