RGD Reference Report - Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. - Rat Genome Database

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Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma.

Authors: Chen, Jie  Zhang, Jie  Liu, Xi  Fang, Rui  Zhao, Yueran  Ma, Demei 
Citation: Chen J, etal., Oncol Rep. 2014 Jun;31(6):2601-10. doi: 10.3892/or.2014.3139. Epub 2014 Apr 16.
RGD ID: 42722607
Pubmed: PMID:24737201   (View Abstract at PubMed)
DOI: DOI:10.3892/or.2014.3139   (Journal Full-text)

Fibulin-4, a member of the fibulin family of extracellular glycoproteins, is implicated in the progression of a number of types of cancer. However, the function of fibulin-4 in cervical cancer progression remains unexplored. Fibulin-4 mRNA and protein expression levels in normal cervical tissue, cervical intraepithelial neoplasia (CIN), cervical carcinoma, highly invasive subclones and low-invasive subclones were evaluated by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry. Serum fibulin-4 levels in patients with CIN and cervical carcinoma were measured by enzyme-linked immunosorbent assay. To assess the angiogenic properties of fibulin-4, vascular endothelial growth factor (VEGF) expression and tumor microvessel density (MVD) were analyzed in the cervical carcinoma cases by immunohistochemistry. Fibulin-4 expression was upregulated in the cervical carcinoma cases, and was positively correlated with MVD and VEGF expression. Fibulin-4 overexpression and high serum levels were significantly associated with advanced stage, low differentiation, lymph node metastasis, and poor prognosis in patients with cervical cancer. Fibulin-4 expression was also found to be overexpressed in highly invasive subclones when compared with the low-invasive subclones. Fibulin-4 is a newly identified glycoprotein that is overexpressed in cervical carcinoma. Fibulin-4 promotes angiogenesis and is associated with poor prognostic clinicopathologic features. This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix carcinoma exacerbatesIEP 42722607mRNA and protein:increased expression:cervix epithelium (human)RGD 
cervix carcinoma exacerbatesISOEFEMP2 (Homo sapiens)42722607; 42722607mRNA and protein:increased expression:cervix epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Efemp2  (EGF containing fibulin extracellular matrix protein 2)

Genes (Mus musculus)
Efemp2  (epidermal growth factor-containing fibulin-like extracellular matrix protein 2)

Genes (Homo sapiens)
EFEMP2  (EGF containing fibulin extracellular matrix protein 2)


Additional Information