RGD Reference Report - Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. - Rat Genome Database

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Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis.

Authors: Latzin, P  Hartl, D  Regamey, N  Frey, U  Schoeni, MH  Casaulta, C 
Citation: Latzin P, etal., Eur Respir J. 2008 Jan;31(1):36-42. Epub 2007 Sep 26.
RGD ID: 4145612
Pubmed: (View Article at PubMed) PMID:17898016
DOI: Full-text: DOI:10.1183/09031936.00078107

The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) is a challenge. Thymus- and activation-regulated chemokine (TARC) has recently been reported to play a role in ABPA. The aim of this study was to compare the diagnostic value of TARC with that of known serological markers for diagnosis of ABPA in CF patients. The present study longitudinally followed 48 CF patients, of whom 12 had a diagnosis of ABPA according to Nelson's criteria, for 1-8 yrs with repeated measurements of serum total immunoglobulin (Ig)E, specific Aspergillus fumigatus IgE and IgG, specific IgE against recombinant A. fumigatus allergens (rAsp f) 1, 3, 4 and 6, and TARC. Median (interquartile range) TARC levels were 589 (465-673) pg x mL(-1) in ABPA patients and 232 (189-289) pg x mL(-1) in non-ABPA patients. Receiver operating characteristic curves revealed that TARC was superior to the other markers for diagnosis of ABPA. Diagnostic accuracy was greater for TARC (93%) than for total IgE (74%), or rAsp f 4 (75%) or f 6 (79%). The present study indicates that thymus- and activation-regulated chemokine may be useful in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients. However, larger studies are needed before thymus- and activation-regulated chemokine can routinely be used in diagnostic algorithms.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ccl17  (C-C motif chemokine ligand 17)

Genes (Mus musculus)
Ccl17  (chemokine (C-C motif) ligand 17)

Genes (Homo sapiens)
CCL17  (C-C motif chemokine ligand 17)


Additional Information