RGD Reference Report - Polymorphisms of the beta2 adrenoreceptor gene in chronic obstructive pulmonary disease. - Rat Genome Database

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Polymorphisms of the beta2 adrenoreceptor gene in chronic obstructive pulmonary disease.

Authors: Vacca, G  Schwabe, K  Duck, R  Hlawa, HP  Westphal, A  Pabst, S  Grohe, C  Gillissen, A 
Citation: Vacca G, etal., Ther Adv Respir Dis. 2009 Feb;3(1):3-10.
RGD ID: 4145082
Pubmed: PMID:19293197   (View Abstract at PubMed)
DOI: DOI:10.1177/1753465809102553   (Journal Full-text)

BACKGROUND: The beta2-adrenergic receptors are cell surface receptors playing a central role in the pharmacological targeting asthma and chronic obstructive pulmonary disease [COPD]. Recent studies suggest that patients who are homozygous for one of the two important polymorphisms of the beta2-adrenergic receptor [ADRB2] gene at codon 16 (arginine to glycine) and 27 (glutamine to glutamate) may have a reduced response to ss2-agonists. Since smoking patients who are Gly16 homozygotes have an increased risk of airway obstruction we hypothesized that beta2-adrenoreceptor gene polymorphisms may be also a cofounder for COPD development and disease severity. METHODS: We investigated 190 COPD patients and 172 healthy volunteers in a case-control study. DNA was isolated from whole blood and beta2-AR gene polymorphisms Arg/Gly16 and Gln/Glu27 were determined using allele-specific polymerase chain reaction [PCR]. RESULTS: In COPD patients with Gly/Gly16 was found more frequently than in healthy smokers [29.47% COPD versus 18.18% controls, p = 0.026]. All other gene polymorphisms of the ADRB2 gene at codon 16 were equally distributed between groups. ss2-adrenoreceptor gene polymorphisms were neither a cofounder for COPD exacerbations [>or= 3 hospitalizations within the last 3 years] nor for disease severity [FEV1

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic obstructive pulmonary disease no_associationIAGP 4145082DNA:polymorphism: :p.Q27E (human)RGD 
chronic obstructive pulmonary disease no_associationISOADRB2 (Homo sapiens)4145082; 4145082DNA:polymorphism: :p.Q27E (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb2  (adrenoceptor beta 2)

Genes (Mus musculus)
Adrb2  (adrenergic receptor, beta 2)

Genes (Homo sapiens)
ADRB2  (adrenoceptor beta 2)


Additional Information