RGD Reference Report - Calcium binding to polypeptides of rat liver and Zajdela hepatoma mitochondrial inner membranes. - Rat Genome Database

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Calcium binding to polypeptides of rat liver and Zajdela hepatoma mitochondrial inner membranes.

Authors: Evtodienko, YV  Azarashvili, TS  Kudin, AP 
Citation: Evtodienko YV, etal., FEBS Lett. 1998 Feb 13;423(1):45-8.
RGD ID: 4144103
Pubmed: PMID:9506839   (View Abstract at PubMed)

Composition and amount of 45Ca2+-binding proteins in the inner membrane fraction of rat liver and Zajdela hepatoma mitochondria were determined. In the inner membrane of liver mitochondria, three major 45Ca2+-binding polypeptides: a protein of approximately 130 kDa (carbamoyl-phosphate synthetase), a glycoprotein of 43-44 kDa (previously considered as the calcium uniporter), and 29-30 kDa protein were found. These components were absent (130 kDa component) or relatively reduced (43-44 kDa and 29-30 kDa components) in the inner membrane of hepatoma mitochondria. Previously unknown low molecular mass polypeptides, having very high Ca2+-binding ability, were found in the inner membrane of hepatoma mitochondria. One of them might be the natural Ca2+-binding inhibitor of H+-ATPase.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
calcium ion binding  IPIPubChem_Compound:63354934144103 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cps1  (carbamoyl-phosphate synthase 1)


Additional Information