RGD Reference Report - YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia. - Rat Genome Database

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YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.

Authors: Cantwell, AM  Bubeck, SS  Dube, PH 
Citation: Cantwell AM, etal., BMC Immunol. 2010 Jun 16;11:29.
RGD ID: 4142820
Pubmed: PMID:20565713   (View Abstract at PubMed)
PMCID: PMC2894752   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2172-11-29   (Journal Full-text)

BACKGROUND: Yersinia pestis is the causative agent of pneumonic plague; recently, we and others reported that during the first 24-36 hours after pulmonary infection with Y. pestis pro-inflammatory cytokine expression is undetectable in lung tissues. RESULTS: Here, we report that, intranasal infection of mice with CO92 delta yopH mutant results in an early pro-inflammatory response in the lungs characterized by an increase in the pro-inflammatory cytokines Tumor Necrosis Factor-alpha and Interleukin one-beta 24 hours post-infection. CO92 delta yopH colonizes the lung but does not disseminate to the liver or spleen and is cleared from the host within 72 hours post-infection. This is different from what is observed in a wild-type CO92 infection, where pro-inflammatory cytokine expression and immune cell infiltration into the lungs is not detectable until 36-48 h post-infection. CO92 rapidly disseminates to the liver and spleen resulting in high bacterial burdens in these tissues ultimately cumulating in death 72-94 h post-infection. Mice deficient in TNF-alpha are more susceptible to CO92 delta yopH infection with 40% of the mice succumbing to infection. CONCLUSIONS: Altogether, our results suggest that YopH can inhibit an early pro-inflammatory response in the lungs of mice and that this is an important step in the pathogenesis of infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanplague  ISOIl1b (Mus musculus) RGD 
Il1bRatplague  ISOIl1b (Mus musculus) RGD 
Il1bMouseplague  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information