RGD Reference Report - The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. - Rat Genome Database

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The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.

Authors: Lenzen, S  Tiedge, M  Elsner, M  Lortz, S  Weiss, H  Jörns, A  Klöppel, G  Wedekind, D  Prokop, C M  Hedrich, H J 
Citation: Lenzen S, etal., Diabetologia. 2001 Sep;44(9):1189-96. doi: 10.1007/s001250100625.
RGD ID: 41412198
Pubmed: PMID:11596676   (View Abstract at PubMed)
DOI: DOI:10.1007/s001250100625   (Journal Full-text)


AIMS/HYPOTHESIS: We describe a new Type I (insulin-dependent) diabetes mellitus rat model (LEW.1AR1/Ztm-iddm) which arose through a spontaneous mutation in a congenic Lewis rat strain with a defined MHC haplotype (RT1.Aa B/Du Cu).
METHODS: The development of diabetes was characterised using biochemical, immunological and morphological methods.
RESULTS: Diabetes appeared in the rats with an incidence of 20 % without major sex preference at 58+/-2 days. The disease was characterised by hyperglycaemia, glycosuria, ketonuria and polyuria. In peripheral blood, the proportion of T lymphocytes was in the normal range expressing the RT6.1 differentiation antigen. Islets were heavily infiltrated with B and T lymphocytes, macrophages and NK cells with beta cells rapidly destroyed through apoptosis in areas of insulitis.
CONCLUSION/INTERPRETATION: This Type I diabetic rat develops a spontaneous insulin-dependent autoimmune diabetes through beta cell apoptosis. It could prove to be a valuable new animal model for clarifying the mechanisms involved in the development of autoimmune diabetes.



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LEW.1AR1-iddm/Ztm  (NA)


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