RGD Reference Report - The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.

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The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.
Authors:	Thelen, Tennille Hao, Yibai Medeiros, Alexandra I Curtis, Jeffrey L Serezani, Carlos H Kobzik, Lester Harris, Lisa H Aronoff, David M
Citation:	Thelen T, etal., J Immunol. 2010 Oct 1;185(7):4328-35. doi: 10.4049/jimmunol.1000989. Epub 2010 Sep 1.
RGD ID:	41412193
Pubmed:	PMID:20810988 (View Abstract at PubMed)
PMCID:	PMC7682803 (View Article at PubMed Central)
DOI:	DOI:10.4049/jimmunol.1000989 (Journal Full-text)
Clostridium sordellii is an emerging pathogen associated with highly lethal female reproductive tract infections following childbirth, abortion, or cervical instrumentation. Gaps in our understanding of the pathogenesis of C. sordellii infections present major challenges to the development of better preventive and therapeutic strategies against this problem. We sought to determine the mechanisms whereby uterine decidual macrophages phagocytose this bacterium and tested the hypothesis that human decidual macrophages use class A scavenger receptors to internalize unopsonized C. sordellii. In vitro phagocytosis assays with human decidual macrophages incubated with pharmacological inhibitors of class A scavenger receptors (fucoidan, polyinosinic acid, and dextran sulfate) revealed a role for these receptors in C. sordellii phagocytosis. Soluble macrophage receptor with collagenous structure (MARCO) receptor prevented C. sordellii internalization, suggesting that MARCO is an important class A scavenger receptor in decidual macrophage phagocytosis of this microbe. Peritoneal macrophages from MARCO-deficient mice, but not wild-type or scavenger receptor AI/II-deficient mice, showed impaired C. sordellii phagocytosis. MARCO-null mice were more susceptible to death from C. sordellii uterine infection than wild-type mice and exhibited impaired clearance of this bacterium from the infected uterus. Thus, MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
MARCO	Human	Clostridium Infections	exacerbates	ISO	Marco (Mus musculus)		RGD
Marco	Mouse	Clostridium Infections	exacerbates	IMP			RGD
Marco	Rat	Clostridium Infections	exacerbates	ISO	Marco (Mus musculus)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Marco (macrophage receptor with collagenous structure)

Genes (Mus musculus)

Marco (macrophage receptor with collagenous structure)

Genes (Homo sapiens)

MARCO (macrophage receptor with collagenous structure)

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The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.