RGD Reference Report - Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. - Rat Genome Database

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Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.

Authors: McNab, Finlay W  Berry, Matthew P R  Graham, Christine M  Bloch, Susannah A A  Oni, Tolu  Wilkinson, Katalin A  Wilkinson, Robert J  Kon, Onn M  Banchereau, Jacques  Chaussabel, Damien  O'Garra, Anne 
Citation: McNab FW, etal., Eur J Immunol. 2011 Jul;41(7):1941-7. doi: 10.1002/eji.201141421. Epub 2011 May 27.
RGD ID: 41412173
Pubmed: PMID:21509782   (View Abstract at PubMed)
PMCID: PMC3179592   (View Article at PubMed Central)
DOI: DOI:10.1002/eji.201141421   (Journal Full-text)

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's largest infectious disease problems. Despite decades of intensive study, the immune response to Mtb is incompletely characterised, reflecting the extremely complex interaction between pathogen and host. Pathways that may alter the balance between host protection and pathogenesis are therefore of great interest. One pathway shown to play a role in the pathogenesis of chronic infections, including TB, is the programmed death-1 (PD-1) pathway. We show here that the expression of the programmed death ligand 1 (PD-L1), which interacts with PD-1, is increased in whole blood from active TB patients compared with whole blood from healthy controls or Mtb-exposed individuals, and that expression by neutrophils is largely responsible for this increase.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tuberculosis  IEP 41412173mRNA more ...RGD 
tuberculosis  ISOCD274 (Homo sapiens)41412173; 41412173mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd274  (CD274 molecule)

Genes (Mus musculus)
Cd274  (CD274 antigen)

Genes (Homo sapiens)
CD274  (CD274 molecule)


Additional Information