RGD Reference Report - Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. - Rat Genome Database
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Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

Authors: Matsumine, A  Ogai, A  Senda, T  Okumura, N  Satoh, K  Baeg, G H  Kawahara, T  Kobayashi, S  Okada, M  Toyoshima, K  Akiyama, T 
Citation: Matsumine A, etal., Science. 1996 May 17;272(5264):1020-3. doi: 10.1126/science.272.5264.1020.
RGD ID: 40902971
Pubmed: (View Article at PubMed) PMID:8638125
DOI: Full-text: DOI:10.1126/science.272.5264.1020

The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein beta-catenin. Overexpression of APC blocks cell cycle progression. The APC-beta-catenin complex was shown to bind to DLG, the human homolog of the Drosophila discs large tumor suppressor protein. This interaction required the carboxyl-terminal region of APC and the DLG homology repeat region of DLG. APC colocalized with DLG at the lateral cytoplasm in rat colon epithelial cells and at the synapse in cultured hippocampal neurons. These results suggest that the APC-DLG complex may participate in regulation of both cell cycle progression and neuronal function.

Annotation

Gene Ontology Annotations    

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Apc  (APC regulator of WNT signaling pathway)
Dlg1  (discs large MAGUK scaffold protein 1)


Additional Information