RGD Reference Report - Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection. - Rat Genome Database

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Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection.

Authors: Wang, Tianying  Chen, Shuang  Wang, Xueqing  Huang, Yike  Qiu, Jianfa  Fei, Yanru  Chaulagain, Anita  Chen, Yang  Wang, Yan  Lin, Lexun  Yan, Biying  Wang, Ying  Wang, Wei  Zhao, Wenran  Zhong, Zhaohua 
Citation: Wang T, etal., Antiviral Res. 2019 Jun;166:1-10. doi: 10.1016/j.antiviral.2019.03.007. Epub 2019 Mar 20.
RGD ID: 40818421
Pubmed: (View Article at PubMed) PMID:30904424
DOI: Full-text: DOI:10.1016/j.antiviral.2019.03.007

Coxsackievirus group B (CVB) is considered as one of the most common pathogens of human viral myocarditis. CVB-induced myocarditis is mainly characterized by the persistence of the virus infection and immune-mediated inflammatory injury. Costimulatory signals are crucial for the activation of adaptive immunity. Our data reveal that the CVB type 3 (CVB3) infection altered the expression profile of costimulatory molecules in host cells. CVB3 infection caused the decrease of PD-1 ligand expression, partially due to the cleavage of AU-rich element binding protein AUF1 by the viral protease 3Cpro, leading to the exacerbated inflammatory injury of the myocardium. Moreover, systemic PD-L1 treatment, which augmented the apoptosis of proliferating lymphocytes, alleviated myocardial inflammatory injury. Our findings suggest that PD1-pathway can be a potential immunologic therapeutic target for CVB-induced myocarditis.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Cd274  (CD274 molecule)
Pdcd1lg2  (programmed cell death 1 ligand 2)

Genes (Mus musculus)
Cd274  (CD274 antigen)
Pdcd1lg2  (programmed cell death 1 ligand 2)

Genes (Homo sapiens)
CD274  (CD274 molecule)
PDCD1LG2  (programmed cell death 1 ligand 2)


Additional Information