RGD Reference Report - Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A. - Rat Genome Database

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Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A.

Authors: Cho, Hyosun  Kang, Hyojeung  Kim, Chang Wook  Kim, Hee Yeon  Jang, Jeong Won  Yoon, Seung Kew  Lee, Chang Don 
Citation: Cho H, etal., Gut Liver. 2016 Mar;10(2):288-94. doi: 10.5009/gnl14368.
RGD ID: 40818419
Pubmed: (View Article at PubMed) PMID:26347518
DOI: Full-text: DOI:10.5009/gnl14368


BACKGROUND/AIMS: The immunoregulatory molecules programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are associated with the dysfunction of antiviral effector T-cells, which leads to T-cell exhaustion and persistent viral infection in patients with chronic hepatitis C and chronic hepatitis B. Little is known about the role of PD-1 and CTLA-4 in patients with symptomatic acute hepatitis A (AHA).
METHODS: Peripheral blood mononuclear cells were isolated from seven patients with AHA and from six patients with nonviral acute toxic hepatitis (ATH) during the symptomatic and convalescent phases of the respective diseases; five healthy subjects acted as controls. The expression of PD-1 and CTLA-4 on T-cells was measured by flow cytometry.
RESULTS: PD-1 and CTLA-4 expression during the symptomatic phase was significantly higher in the T-cells of AHA patients than in those of ATH patients or healthy controls (PD-1 18.3% vs 3.7% vs 1.6%, respectively, p<0.05; CTLA-4 23.5% vs 6.1% vs 5.9%, respectively, p<0.05). The levels of both molecules decreased dramatically during the convalescent phase of AHA, whereas a similar pattern was not seen in ATH.
CONCLUSIONS: Our findings are consistent with a viral-protective effect of PD-1 and CTLA-4 as inhibitory molecules that suppress cytotoxic T-cells and thereby prevent the destruction of virus-infected hepatocytes in AHA.



Disease Annotations    
hepatitis A  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)
Pdcd1  (programmed cell death 1)

Genes (Mus musculus)
Ctla4  (cytotoxic T-lymphocyte-associated protein 4)
Pdcd1  (programmed cell death 1)

Genes (Homo sapiens)
CTLA4  (cytotoxic T-lymphocyte associated protein 4)
PDCD1  (programmed cell death 1)


Additional Information