RGD Reference Report - Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. - Rat Genome Database

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Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis.

Authors: Matsumoto, Kazuyuki  Miyake, Yasuhiro  Matsushita, Hiroshi  Ohnishi, Atsuyuki  Ikeda, Fusao  Shiraha, Hidenori  Takaki, Akinobu  Nouso, Kazuhiro  Yamamoto, Kazuhide 
Citation: Matsumoto K, etal., J Gastroenterol Hepatol. 2014 Jan;29(1):110-5. doi: 10.1111/jgh.12340.
RGD ID: 40818236
Pubmed: PMID:23869988   (View Abstract at PubMed)
DOI: DOI:10.1111/jgh.12340   (Journal Full-text)


BACKGROUND AND AIM: Recently, the association of the dysfunction of programmed cell death (PD)-1 expressed on activated lymphocytes with the pathogenesis of autoimmune hepatitis (AIH) has been speculated. This study aimed to investigate the association of serum anti-PD-1 antibodies with clinical characteristics of type 1 AIH.
METHODS: Serum samples before the initiation of prednisolone treatment were obtained from 52 type 1 AIH patients, 24 patients with drug-induced liver injury (DILI), 30 patients with acute viral hepatitis (AVH), 11 patients with primary sclerosing cholangitis (PSC), and 62 healthy volunteers. Titers of serum anti-PD-1 antibodies were measured by indirect enzyme-linked immunosorbent assay. The cutoff level was represented by a mean absorbance + 2 standard deviations in healthy volunteers.
RESULTS: Prevalence of serum anti-PD-1 antibodies was 63% in type 1 AIH patients, 8% in DILI patients, 13% in AVH patients, 18% in PSC patients, and 3% in healthy volunteers. In type 1 AIH patients, titers of serum anti-PD-1 antibodies were correlated with serum levels of bilirubin (r = 0.31, P = 0.030) and alanine aminotransferase (r = 0.31, P = 0.027) but not serum immunoglobulin G levels. Positivity for serum anti-PD-1 antibodies was associated with the later normalization of serum alanine aminotransferase levels after the initiation of prednisolone and the disease relapse.
CONCLUSIONS: Serum anti-PD-1 antibodies would be useful for the discrimination of type 1 AIH from DILI, AVH, and PSC as an auxiliary diagnostic marker. Furthermore, anti-PD-1 antibodies may be associated with clinical characteristics of type 1 AIH.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autoimmune hepatitis  IDA 40818236 RGD 
autoimmune hepatitis  ISOPDCD1 (Homo sapiens)40818236; 40818236 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdcd1  (programmed cell death 1)

Genes (Mus musculus)
Pdcd1  (programmed cell death 1)

Genes (Homo sapiens)
PDCD1  (programmed cell death 1)


Additional Information