RGD Reference Report - Red Blood Cells Store and Release Interleukin-33. - Rat Genome Database

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Red Blood Cells Store and Release Interleukin-33.

Authors: Wei, Jianxin  Zhao, Jing  Schrott, Valerie  Zhang, Yingze  Gladwin, Mark  Bullock, Grant  Zhao, Yutong 
Citation: Wei J, etal., J Investig Med. 2015 Aug;63(6):806-10. doi: 10.1097/JIM.0000000000000213.
RGD ID: 40400691
Pubmed: (View Article at PubMed) PMID:26107423
DOI: Full-text: DOI:10.1097/JIM.0000000000000213

Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives production of a variety of cytokines and contributes to the pathogenesis of inflammatory diseases. The IL-33 is a nuclear protein and is released from apoptotic or necrotic cells. Serum IL-33 levels are increased in various diseases, such as atopic dermatitis, chronic hepatitis C infection, and asthma. Here, we show that red blood cells (RBCs) are one of the major sources of plasma IL-33. The IL-33 levels are significantly increased in supernatants from lysed RBCs. Plasma IL-33 levels are increased in patients during hemolysis, and plasma IL-33 levels show a positive correlation with degree of hemolysis. The IL-33 protein and messenger RNA levels were detected in the late stages of differentiation in ex vivo primary human erythroid progenitor cell cultures, suggesting that IL-33 is expressed during maturation of RBCs. Furthermore, hemoglobin depleted red cell lysates induced IL-8 expression in human epithelial cells. This effect was attenuated in IL-33 decoy receptor expressing cells and was enhanced in IL-33 receptor expressing cells. These results suggest that erythroid progenitor cells produce IL-33 and circulating RBCs represent a major source of IL-33 that is released upon hemolysis.


Disease Annotations    
Hemolysis  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Il33  (interleukin 33)

Genes (Mus musculus)
Il33  (interleukin 33)

Genes (Homo sapiens)
IL33  (interleukin 33)

Additional Information