RGD Reference Report - Effects of intranasally-delivered pro-nerve growth factors on the septo-hippocampal system in healthy and diabetic rats. - Rat Genome Database

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Effects of intranasally-delivered pro-nerve growth factors on the septo-hippocampal system in healthy and diabetic rats.

Authors: Soligo, Marzia  Protto, Virginia  Chiaretti, Antonio  Piccinin, Sonia  De Stefano, Maria Egle  Nisticò, Robert  Bracci-Laudiero, Luisa  Manni, Luigi 
Citation: Soligo M, etal., Neuropharmacology. 2020 Oct 1;176:108223. doi: 10.1016/j.neuropharm.2020.108223. Epub 2020 Jul 15.
RGD ID: 402463968
Pubmed: PMID:32681844   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuropharm.2020.108223   (Journal Full-text)

Pro-nerve growth factor (proNGF) is the predominant form of NGF in the brain and its levels increase in neurodegenerative diseases. The balance between NGF receptors may explain the contradictory biological activities of proNGF. However, the specific role of the two main proNGF variants is mostly unexplored. proNGF-A is prevalently expressed in healthy brain, while proNGF-B content increases in the neuro-degenerating brain. Recently we have investigated in vitro the biological action of native mouse proNGF variants. To gain further insights into the specific functions of the two proNGFs, here we intranasally delivered mouse-derived proNGF-A and proNGF-B to the brain parenchyma of healthy and diabetic rats, the latter characterized by dysfunction in spatial learning and memory, in the septo-hippocampal circuitry and by relative increase in proNGF-B hippocampal levels. Exogenous proNGF-B induces depression of hippocampal DG-LTP and impairment of hippocampal neurogenesis in healthy animals, with concomitant decrease in basal forebrain cholinergic neurons and cholinergic fibers projecting to the hippocampus. proNGF-A, while ineffective in healthy animals, rescues the diabetes-induced impairment in DG-LTP and hippocampal neurogenesis, promoting the concomitant recovery of the basal forebrain cholinergic phenotype. Our experimental evidences suggest that the balance between different proNGFs may influence the development and progression of neurodegenerative diseases.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGFHumandiabetic encephalopathy treatmentISONgf (Mus musculus)associated with Experimental Diabetes MellitusRGD 
NgfMousediabetic encephalopathy treatmentIMP associated with Experimental Diabetes MellitusRGD 
NgfRatdiabetic encephalopathy treatmentISONgf (Mus musculus)associated with Experimental Diabetes MellitusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngf  (nerve growth factor)

Genes (Mus musculus)
Ngf  (nerve growth factor)

Genes (Homo sapiens)
NGF  (nerve growth factor)


Additional Information