RGD Reference Report - Tobacco smoking and the ADRA2A C-1291G polymorphism. - Rat Genome Database

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Tobacco smoking and the ADRA2A C-1291G polymorphism.

Authors: Prestes, A P  Marques, F Z C  Hutz, M H  Roman, T  Bau, C H D 
Citation: Prestes AP, etal., J Neural Transm (Vienna). 2007;114(11):1503-6. doi: 10.1007/s00702-007-0769-6. Epub 2007 Jul 6.
RGD ID: 401976458
Pubmed: PMID:17612790   (View Abstract at PubMed)
DOI: DOI:10.1007/s00702-007-0769-6   (Journal Full-text)

The aim of the present study is to test for possible associations between the C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) with tobacco smoking and alcohol dependence. The genotype and allele frequencies were compared in three groups of European-derived Brazilian males: individuals with co-occurrence of tobacco smoking and alcohol dependence (N = 110), with tobacco smoking (N = 121) and controls (N = 114). The frequency of the G allele was higher in the group with both conditions, intermediate among subjects with smoking, and lower among controls (chi(2) = 8.00; p = 0.02). The chi(2) partitioning did not reveal significant differences between the sample with the two conditions and the sample of smokers (chi(2) = 0.82; p = 0.36). Combining both groups, the difference to the non-smoking controls is higher than the one observed in the three-groups analysis (chi(2) = 7.18; p = 0.007). The results suggest a role for the ADRA2A C-1291G polymorphism, notably the G allele, in the predisposition to tobacco smoking. The influence of the ADRA2A gene in nicotine and other substance dependencies should be more extensively assessed in future studies.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRA2AHumannicotine dependence susceptibilityIAGP DNA:SNP:promoter: C-1291G (rs1800544) (human)RGD 
Adra2aRatnicotine dependence susceptibilityISOADRA2A (Homo sapiens)DNA:SNP:promoter: C-1291G (rs1800544) (human)RGD 
Adra2aMousenicotine dependence susceptibilityISOADRA2A (Homo sapiens)DNA:SNP:promoter: C-1291G (rs1800544) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRA2AHumanAddictive nicotine use susceptibilityIAGP DNA:SNP:promoter: C-1291G (rs1800544) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Adra2a  (adrenoceptor alpha 2A)

Genes (Mus musculus)
Adra2a  (adrenergic receptor, alpha 2a)

Genes (Homo sapiens)
ADRA2A  (adrenoceptor alpha 2A)


Additional Information