RGD Reference Report - Tryptophan catabolism reflects disease activity in human tuberculosis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Tryptophan catabolism reflects disease activity in human tuberculosis.

Authors: Collins, Jeffrey M  Siddiqa, Amnah  Jones, Dean P  Liu, Ken  Kempker, Russell R  Nizam, Azhar  Shah, N Sarita  Ismail, Nazir  Ouma, Samuel G  Tukvadze, Nestani  Li, Shuzhao  Day, Cheryl L  Rengarajan, Jyothi  Brust, James Cm  Gandhi, Neel R  Ernst, Joel D  Blumberg, Henry M  Ziegler, Thomas R 
Citation: Collins JM, etal., JCI Insight. 2020 May 21;5(10). pii: 137131. doi: 10.1172/jci.insight.137131.
RGD ID: 39939073
Pubmed: PMID:32369456   (View Abstract at PubMed)
PMCID: PMC7259525   (View Article at PubMed Central)
DOI: DOI:10.1172/jci.insight.137131   (Journal Full-text)

There is limited understanding of the role of host metabolism in the pathophysiology of human tuberculosis (TB). Using high-resolution metabolomics with an unbiased approach to metabolic pathway analysis, we discovered that the tryptophan pathway is highly regulated throughout the spectrum of TB infection and disease. This regulation is characterized by increased catabolism of tryptophan to kynurenine, which was evident not only in active TB disease but also in latent TB infection (LTBI). Further, we found that tryptophan catabolism is reversed with effective treatment of both active TB disease and LTBI in a manner commensurate with bacterial clearance. Persons with active TB and LTBI also exhibited increased expression of indoleamine 2,3-dioxygenase-1 (IDO-1), suggesting IDO-1 mediates observed increases in tryptophan catabolism. Together, these data indicate IDO-1-mediated tryptophan catabolism is highly preserved in the human response to Mycobacterium tuberculosis and could be a target for biomarker development as well as host-directed therapies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acquired immunodeficiency syndrome  IEP 39939073associated with pulmonary tuberculosis and protein:increased expression:blood (human)RGD 
acquired immunodeficiency syndrome  ISOIDO1 (Homo sapiens)39939073; 39939073associated with pulmonary tuberculosis and protein:increased expression:blood (human)RGD 
pulmonary tuberculosis treatmentIEP 39939073 RGD 
pulmonary tuberculosis treatmentISOIDO1 (Homo sapiens)39939073; 39939073 RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
kynurenine metabolic pathway   IEP 39939073 RGD 
kynurenine metabolic pathway   ISOIDO1 (Homo sapiens)39939073; 39939073 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ido1  (indoleamine 2,3-dioxygenase 1)

Genes (Mus musculus)
Ido1  (indoleamine 2,3-dioxygenase 1)

Genes (Homo sapiens)
IDO1  (indoleamine 2,3-dioxygenase 1)


Additional Information