RGD Reference Report - Polymorphism of DC-SIGN (CD209) promoter in association with clinical symptoms of dengue fever. - Rat Genome Database

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Polymorphism of DC-SIGN (CD209) promoter in association with clinical symptoms of dengue fever.

Authors: Oliveira, Layanna Freitas de  Lima, Clayton Pereira Silva de  Azevedo, Raimunda do Socorro Silva  Mendonça, Dafne Silva Furtado de  Rodrigues, Sueli Guerreiro  Carvalho, Valéria Lima  Pinto, Eliana Vieira  Maia, Andreza Lopes  Maia, Maria Helena Thomaz  Vasconcelos, Janaina Mota  Silva, Andrea Luciana Soares da  Nunes, Márcio Roberto Teixeira  Sena, Leonardo  Vasconcelos, Pedro Fernando  Santos, Eduardo José Melo dos 
Citation: Oliveira LF, etal., Viral Immunol. 2014 Jun;27(5):245-9. doi: 10.1089/vim.2013.0119. Epub 2014 May 5.
RGD ID: 39939060
Pubmed: PMID:24797508   (View Abstract at PubMed)
DOI: DOI:10.1089/vim.2013.0119   (Journal Full-text)

C-type lectin DC-SIGN receptor, encoded by CD209, plays a key role in the infection of dendritic cells by dengue virus (DENV). Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis. A control sample of 72 individuals, rigorously selected through a clinical investigation for absence of past dengue fever (DF) was compared to a sample of 168 patients (156 classical DF; 12 dengue hemorrhagic fever), all residents from Pará, Brazil. However, the prevalence of symptoms showed a trend higher in the AA genotype (Wilcoxon test; Z=2.02; p=0.04). Hence, our findings indicate that the G allele downregulates the spectrum of symptoms during the early acute phase of DENV infection, putatively decreasing the viremia, as suggested in the literature.

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Arthralgia/arthritis  IAGP 39939060DNA:SNP:promoter:-336A>G SNP (rs4804803) (human)RGD 
Headache  IAGP 39939060DNA:SNP:promoter:-336A>G SNP (rs4804803) (human)RGD 
Objects Annotated

Genes (Homo sapiens)
CD209  (CD209 molecule)


Additional Information