RGD Reference Report - Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis. - Rat Genome Database

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Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis.

Authors: Moniuszko, Anna  Czupryna, Piotr  Pancewicz, Sławomir  Rutkowski, Krzysztof  Zajkowska, Olga  Swierzbińska, Renata  Grygorczuk, Sambor  Kondrusik, Maciej  Owłasiuk, Piotr  Zajkowska, Joanna 
Citation: Moniuszko A, etal., Immunol Lett. 2014 Jan-Feb;157(1-2):45-50. doi: 10.1016/j.imlet.2013.11.002. Epub 2013 Nov 12.
RGD ID: 39939054
Pubmed: PMID:24239846   (View Abstract at PubMed)
DOI: DOI:10.1016/j.imlet.2013.11.002   (Journal Full-text)


PURPOSE: Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB.
RESULTS: There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed.
CONCLUSIONS: CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCL8HumanLyme Neuroborreliosis treatmentIEP  RGD 

Objects Annotated

Genes (Homo sapiens)
CXCL8  (C-X-C motif chemokine ligand 8)


Additional Information