RGD Reference Report - A variant in the CD209 promoter is associated with severity of dengue disease. - Rat Genome Database

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A variant in the CD209 promoter is associated with severity of dengue disease.

Authors: Sakuntabhai, Anavaj  Turbpaiboon, Chairat  Casadémont, Isabelle  Chuansumrit, Ampaiwan  Lowhnoo, Tassanee  Kajaste-Rudnitski, Anna  Kalayanarooj, Sita Mint  Tangnararatchakit, Kanchana  Tangthawornchaikul, Nattaya  Vasanawathana, Sirijit  Chaiyaratana, Wathanee  Yenchitsomanus, Pa-Thai  Suriyaphol, Prapat  Avirutnan, Panisadee  Chokephaibulkit, Kulkanya  Matsuda, Fumihiko  Yoksan, Sutee  Jacob, Yves  Lathrop, G Mark  Malasit, Prida  Desprès, Philippe  Julier, Cécile 
Citation: Sakuntabhai A, etal., Nat Genet. 2005 May;37(5):507-13. doi: 10.1038/ng1550. Epub 2005 Apr 17.
RGD ID: 39938993
Pubmed: (View Article at PubMed) PMID:15838506
DOI: Full-text: DOI:10.1038/ng1550

Dengue fever and dengue hemorrhagic fever are mosquito-borne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 x 10(-7)) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 x 10(-6)). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Cd209  (CD209 molecule)

Genes (Homo sapiens)
CD209  (CD209 molecule)


Additional Information