RGD Reference Report - Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression. - Rat Genome Database

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Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression.

Authors: Zhang, Cheng-Liang  Zhang, Si  He, Wen-Xi  Lu, Jing-Li  Xu, Yan-Jiao  Yang, Jin-Yu  Liu, Dong 
Citation: Zhang CL, etal., Life Sci. 2017 Oct 1;186:125-132. doi: 10.1016/j.lfs.2017.08.010. Epub 2017 Aug 9.
RGD ID: 39938966
Pubmed: PMID:28802904   (View Abstract at PubMed)
DOI: DOI:10.1016/j.lfs.2017.08.010   (Journal Full-text)


AIMS: To investigate the therapeutic effect of baicalin treatment in chronic ulcerative colitis (UC), and explore the potential anti-inflammation mechanism(s) via IL-33 pathway.
MAIN METHODS: UC model were established by giving three cycles of 5-day 2% dextran sodium sulfate (DSS) with two intervals of 14-day recovery in mice, totaling 43days. At the 13th day of the UC modeling, mice received baicalin at doses of 50, 100, or 150mg/kg, respectively. Disease activity index (DAI) assessment as well as HE and PAS staining were performed. Serum levels of TNF-α, IL-1β and IL-6 were determined by ELISA. Myeloperoxidase (MPO) activity and nitric oxide (NO) contents in colon were measured. The expressions of IL-33 and Ly6/G were examined by immunochemistry. And contents of IL-33 protein and NF-κB-related proteins were tested by Western blot.
KEY FINDINGS: Morphological and histological analyses revealed that baicalin administration had a significant effect on reducing the severity of DSS-induced UC in mice. Besides, baicalin treatment significantly reduced the levels of MPO and NO. Moreover, increased levels of inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, have been identified in damaged colon tissue, which was noticeably reduced by baicalin treatment. Our data demonstrated that protein levels of IL-33 and NF-κB p65 were elevated in colon tissues of chronic UC mice. Baicalin treatment significantly suppressed levels of IL-33 and NF-κB p65, whereas levels of IκB-α were increased.
SIGNIFICANCE: Baicalin treatment effectively alleviated DSS-induced chronic UC, and the protective mechanisms may involve inhibition of IL-33 expression and subsequent NF-κB activation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ulcerative colitis treatmentISOIl33 (Mus musculus)39938966; 39938966 RGD 
ulcerative colitis treatmentIEP 39938966 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il33  (interleukin 33)

Genes (Mus musculus)
Il33  (interleukin 33)

Genes (Homo sapiens)
IL33  (interleukin 33)


Additional Information