RGD Reference Report - Association of polymorphisms in serotonin and nitric oxide genes with clinical outcome of dengue in Brazilian northeast population. - Rat Genome Database

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Association of polymorphisms in serotonin and nitric oxide genes with clinical outcome of dengue in Brazilian northeast population.

Authors: Dos Santos, Ana Caroline Melo  de Moura, Edilson Leite  da Silva, Denise Macêdo  Araujo Moura, Alexandre Wendell  Ferreira, Jean Moises  Lira Neto, Abel Barbosa  Pereira E Silva, Aline Cristine  de Medeiros Alves, Verônica  Balliano, Tatiane Luciano  de Farias, Karol Fireman  de Lima Filho, José Luiz  de Souza Figueiredo, Elaine Virgínia Martins 
Citation: Dos Santos ACM, etal., Acta Trop. 2019 Feb;190:144-148. doi: 10.1016/j.actatropica.2018.11.015. Epub 2018 Nov 16.
RGD ID: 38676265
Pubmed: (View Article at PubMed) PMID:30452889
DOI: Full-text: DOI:10.1016/j.actatropica.2018.11.015

Serotonin and nitric oxide seem to be involved in Dengue virus infection. The aim of this study was to investigate if SNPs in serotonin and nitric oxide are associated with dengue severity. A retrospective case-control study was conducted, with groups of dengue fever (DF; n = 78) and dengue hemorrhagic fever patients (DHF; n = 49). Genotyping was performed using qPCR and PCR. The power of the sample size was calculated by G*power software. The heterozygous SL for 5-HTTLPR SNP was significantly correlated with protection against progression to DHF in the codominant SS/SL/LL (OR = 0.22, 95% CI = 0.06-0.81, p = 0.011) and overdominant models SL vs SS + LL (OR = 0.19, 95% CI = 0.06-0.65, p = 0.003). For the ENOS (rs1799983) SNP, the genotype GT was positively associated with protection for development of the clinical form in DHF compared to dengue fever (OR = 0.39, 95% CI = (0.13-1.14), p = 0.0058) in codominant GG/GT/TT and overdominant model GT vs GG + TT (OR = 0.35, 95% CI = (0.12-1.02), p = 0.04). To our knowledge, this is the first study to identify the association of the serotonin and nitric oxide SNPs with dengue severity.

Annotation

Disease Annotations    

Phenotype Annotations    

Human Phenotype
Fever  (IAGP)
Thrombocytopenia  (IAGP)
Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information