RGD Reference Report - The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways. - Rat Genome Database

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The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.

Authors: Shimizu, Shino  Takezawa-Yasuoka, Kumiko  Ogawa, Takao  Tojima, Ichiro  Kouzaki, Hideaki  Shimizu, Takeshi 
Citation: Shimizu S, etal., Clin Immunol. 2018 Mar;188:1-6. doi: 10.1016/j.clim.2017.11.010. Epub 2017 Nov 26.
RGD ID: 38676259
Pubmed: (View Article at PubMed) PMID:29183867
DOI: Full-text: DOI:10.1016/j.clim.2017.11.010

Mucus hypersecretion and eosinophil infiltration are important characteristics of eosinophilic inflammation in upper airways, such as allergic rhinitis and chronic rhinosinusitis with nasal polyp. EGFR transactivation induces mucus and inflammatory cytokine secretion from airway epithelial cells. However, the roles of EGFR in eosinophilic inflammation in upper airways are still unknown. The purpose of the study is to elucidate the effects of the EGFR inhibitor AG1478 on eosinophilic airway inflammation. AG1478 significantly inhibited thrombin-induced GM-CSF secretion from nasal epithelial cells and thrombin-induced secretion of eotaxin-1 and RANTES from nasal fibroblasts. Intranasal instillation of AG1478 inhibited OVA-induced goblet cell metaplasia, mucus production and eosinophil/neutrophil infiltration in rat nasal epithelium, as did intraperitoneal injection of AG1478. These results indicate that EGFR transactivation plays an important role in eosinophilic airway inflammation. Intranasal instillation of an EGFR inhibitor may be a new therapeutic approach for the treatment of intractable eosinophilic inflammation in upper airways.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)


Additional Information