RGD Reference Report - Association between EGFR expression and clinical outcome of laryngeal HPV squamous cell carcinoma. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Association between EGFR expression and clinical outcome of laryngeal HPV squamous cell carcinoma.

Authors: Kontić, Mirko  Čolović, Zaviša  Paladin, Ivan  Gabelica, Mirko  Barić, Ana  Pešutić-Pisac, Valdi 
Citation: Kontić M, etal., Acta Otolaryngol. 2019 Oct;139(10):913-917. doi: 10.1080/00016489.2019.1651938. Epub 2019 Aug 20.
RGD ID: 38599177
Pubmed: (View Article at PubMed) PMID:31430224
DOI: Full-text: DOI:10.1080/00016489.2019.1651938

Background: Expression of the epidermal growth factor receptor (EGFR) and human papillomavirus (HPV) DNA can serve as independent prognostic factors in squamous cell carcinoma (SCC) of the larynx. EGFR correlation with the course of disease and its effect on survival makes EGFR expression a negative prognostic factor, whereas HPV DNA is a positive prognostic factor. Aim: To assess the association of EGFR expression with clinical outcome of laryngeal HPV SCC. Materials and methods: This retrospective study included 196 SCC patients operated on at the Department of ENT, Head and Neck Surgery, Split University Hospital Center in Split, Croatia, between 1 January 2000 and 31 December 2009. Results: The association of HPV infection and EGFR expression was found to be statistically significant, and so was the difference in survival between patient groups with different HPV to EGFR expression ratio. Conclusions: The group of laryngeal HPV SCC patients with increased EGFR expression had shorter survival, confirming EGFR as a major component in predicting patient prognosis and survival. Significance: This article confirms the importance of EGFR expression as a biomarker in laryngeal SCC.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)

Additional Information