RGD Reference Report - Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. - Rat Genome Database

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Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients.

Authors: Kwon, Tack-Kyun  Chung, Eun Jae  Lee, Nuri  Roh, Eun Youn  Song, Eun Young 
Citation: Kwon TK, etal., J Otolaryngol Head Neck Surg. 2017 Mar 15;46(1):21. doi: 10.1186/s40463-017-0197-z.
RGD ID: 38549360
Pubmed: (View Article at PubMed) PMID:28298239
DOI: Full-text: DOI:10.1186/s40463-017-0197-z


BACKGROUND: FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients.
METHODS: A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing.
RESULTS: Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both).
CONCLUSIONS: We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Foxp3  (forkhead box P3)

Genes (Mus musculus)
Foxp3  (forkhead box P3)

Genes (Homo sapiens)
FOXP3  (forkhead box P3)


Additional Information