RGD Reference Report - Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients. - Rat Genome Database

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Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients.

Authors: Wang, Qinghong  Zheng, Yanhua  Huang, Zemin  Tian, Yi  Zhou, Jijun  Mao, Qing  Wu, Yuzhang  Ni, Bing 
Citation: Wang Q, etal., BMC Immunol. 2011 Apr 14;12:25. doi: 10.1186/1471-2172-12-25.
RGD ID: 38549358
Pubmed: PMID:21489307   (View Abstract at PubMed)
PMCID: PMC3094328   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2172-12-25   (Journal Full-text)


BACKGROUND: Foxp3 protein plays a critical role in mediating the inflammatory response and can inhibit the proinflammatory IL-23/IL-17 pathway. However, the molecular interplay of Foxp3 and the IL-23/IL-17 pathway in patients with chronic hepatitis B (CHB) remains unclear. To this end, we analyzed the expression patterns of Foxp3- and IL-23/IL-17 pathway-related proinflammatory cytokines in 39 patients with acute-on-chronic liver failure, 71 patients with CHB and 32 healthy controls.
RESULTS: Foxp3 expression was found to be elevated in and mainly expressed by the CD4+ T cell sub-population of peripheral blood mononuclear cells and liver tissues of patients with hepatitis B. The intrahepatic expression of Foxp3 strongly correlated with the copies of HBV DNA and the concentration of surface antigen, HBsAg. IL-23/IL-17 pathway-related proinflammatory cytokines were also found to be significantly increased in patients' liver tissues, as compared to healthy controls. Moreover, Foxp3 expression was strikingly correlated with the production of these cytokines in liver tissues of CHB patients.
CONCLUSIONS: The closely-correlated increase of Foxp3 and IL-23/IL-17 pathway activity in HBV-infected livers suggests that the proinflammatory IL-23/IL-17 pathway had not been effectively suppressed by the host immune machinery, such as Treg (Foxp3) cells. Constitutive activation of the IL-23/17 pathway, thus, may support the chronic hepatitis B state.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Foxp3  (forkhead box P3)

Genes (Mus musculus)
Foxp3  (forkhead box P3)

Genes (Homo sapiens)
FOXP3  (forkhead box P3)


Additional Information