RGD Reference Report - Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients. - Rat Genome Database

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Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients.

Authors: Herrero-Sánchez, M Carmen  Angomás, Eduardo B  de Ramón, Cristina  Tellería, Juan J  Corchete, Luis A  Alonso, Sara  Ramos, M Del Carmen  Peñarrubia, María J  Márquez, Saioa  Fernández, Nieves  García Frade, Luis J  Sánchez Crespo, Mariano 
Citation: Herrero-Sánchez MC, etal., Infect Immun. 2018 Nov 20;86(12). pii: IAI.00709-18. doi: 10.1128/IAI.00709-18. Print 2018 Dec.
RGD ID: 38501097
Pubmed: PMID:30275011   (View Abstract at PubMed)
PMCID: PMC6246897   (View Article at PubMed Central)
DOI: DOI:10.1128/IAI.00709-18   (Journal Full-text)

High-risk hematological malignancies are a privileged setting for infection by opportunistic microbes, with invasive mycosis being one of the most serious complications. Recently, genetic background has emerged as an unanticipated risk factor. For this reason, polymorphisms for genes encoding archetypal receptors involved in the opsonic and nonopsonic clearance of microbes, pentraxin-3 (PTX3) and Dectin-1, respectively, were studied and correlated with the risk of infection. Fungal, bacterial, and viral infections were registered for a group of 198 patients with high-risk hematological malignancies. Polymorphisms for the pentraxin-3 gene (PTX3) showed a significant association with the risk of fungal infection by Candida spp. and, especially, by Aspergillus spp. This link remained even for patients undergoing antifungal prophylaxis, thus demonstrating the clinical relevance of PTX3 in the defense against fungi. CLEC7A polymorphisms did not show any definite correlation with the risk of invasive mycosis, nor did they influence the expression of Dectin-1 isoforms generated by alternative splicing. The PTX3 mRNA expression level was significantly lower in samples from healthy volunteers who showed these polymorphisms, although no differences were observed in the extents of induction elicited by bacterial lipopolysaccharide and heat-killed Candidaalbicans, thus suggesting that the expression of PTX3 at the start of infection may influence the clinical outcome. PTX3 mRNA expression can be a good biomarker to establish proper antifungal prophylaxis in immunodepressed patients.



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RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTX3Humaninvasive aspergillosis severityIAGP DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527RGD 
Ptx3Mouseinvasive aspergillosis severityISOPTX3 (Homo sapiens)DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527RGD 
Ptx3Ratinvasive aspergillosis severityISOPTX3 (Homo sapiens)DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527RGD 
PTX3HumanInvasive Candidiasis severityIAGP associated with hematologic cancer;DNA:SNP:intron:rs1840680RGD 
Ptx3MouseInvasive Candidiasis severityISOPTX3 (Homo sapiens)associated with hematologic cancer;DNA:SNP:intron:rs1840680RGD 
Ptx3RatInvasive Candidiasis severityISOPTX3 (Homo sapiens)associated with hematologic cancer;DNA:SNP:intron:rs1840680RGD 
PTX3HumanInvasive Fungal Infections severityIAGP DNA:SNPs:intron:rs2305619, rs1840680 (human)RGD 
Ptx3MouseInvasive Fungal Infections severityISOPTX3 (Homo sapiens)DNA:SNPs:intron:rs2305619, rs1840680 (human)RGD 
Ptx3RatInvasive Fungal Infections severityISOPTX3 (Homo sapiens)DNA:SNPs:intron:rs2305619, rs1840680 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptx3  (pentraxin 3)

Genes (Mus musculus)
Ptx3  (pentraxin related gene)

Genes (Homo sapiens)
PTX3  (pentraxin 3)


Additional Information