RGD Reference Report - Serotonin transporter protein overexpression and association to Th17 and T regulatory cells in lupoid leishmaniasis. - Rat Genome Database

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Serotonin transporter protein overexpression and association to Th17 and T regulatory cells in lupoid leishmaniasis.

Authors: Mashayekhi Goyonlo, Vahid  Elnour, Husameldin  Nordlind, Klas 
Citation: Mashayekhi Goyonlo V, etal., Arch Dermatol Res. 2014 Mar;306(2):181-8. doi: 10.1007/s00403-013-1395-9. Epub 2013 Aug 29.
RGD ID: 36947873
Pubmed: PMID:23989888   (View Abstract at PubMed)
DOI: DOI:10.1007/s00403-013-1395-9   (Journal Full-text)

The immunopathogenesis of chronic non-healing Old World cutaneous leishmaniasis is challenging. There is a bidirectional communication between the nervous and immune systems, serotonin being an important mediator in this respect. Our aim was to study the role of the serotonin transporter protein (SERT) and its relation to T cell-related immune responses in lupoid leishmaniasis. Paraffin-embedded skin biopsies of 12 cases of lupoid and 12 cases of usual types of cutaneous leishmaniasis were investigated using immunohistochemistry regarding expression of SERT, Th1, Th2, Th17 and T regulatory cell (Treg) markers. SERT as well as Tregs and interleukin (IL)-17 positive cells were more prevalent while IL-5 (Th2) and interferon (IFN)-γ (Th1) expressing cells were less numerous in the lupoid tissue compared to those from the usual type of leishmaniasis. The majority of the SERT(+) cells were also tryptase(+) (mast cells). There was a positive correlation between a higher number of SERT(+) and IL-17(+) cells in the lupoid type, while lower numbers of SERT(+) cells were significantly related to lower percentages of CD25(+) cells in the usual type of leishmaniasis. These results might indicate a role for SERT, Th17 and Tregs in the pathogenesis of lupoid leishmaniasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
leishmaniasis  IEP 36947873lupoid leishmaniasis and protein:increased expression:skin of body (human)RGD 
leishmaniasis  ISOSLC6A4 (Homo sapiens)36947873; 36947873lupoid leishmaniasis and protein:increased expression:skin of body (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information