RGD Reference Report - Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. - Rat Genome Database

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Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.

Authors: Dong, Van Hieu  Tu, Pang-Yan  Tsai, Pei-Chun  Lin, Yi-Hsin  Chang, Hsiu-Luan  Kuo, Tsun-Yung  Chiou, Ming-Tang  Lin, Chao-Nan  Chung, Wen-Bin 
Citation: Dong VH, etal., Res Vet Sci. 2015 Aug;101:180-6. doi: 10.1016/j.rvsc.2015.05.006. Epub 2015 May 21.
RGD ID: 36049793
Pubmed: (View Article at PubMed) PMID:26022073
DOI: Full-text: DOI:10.1016/j.rvsc.2015.05.006

Pigs co-infected with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) have been shown to develop more severe diseases than pigs infected with PRRSV or PCV2 only. The underlying interaction mechanisms between the two viruses in developing the disease are unclear. The present study investigates the mRNA expression of Toll-like receptor (TLR) signaling-related molecules in peripheral blood mononuclear cells from pigs infected with PRRSV or PCV2 or both. The mRNA expression levels were determined by quantitative real-time RT-PCR. Co-infection of pigs with PRRSV and PCV2 resulted in a negatively synergistic effect on the mRNA expression of the negative regulators of TLR, including A20, Bcl-3, IRAK-M, MKP-1, SARM1 and SIGIRR, as well as the TLR downstream transcription factors IRF-1 and IRF-3. A positively synergistic effect of a combined infection of PRRSV and PCV2 on the CD14 mRNA expression was also observed.

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