RGD Reference Report - The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats. - Rat Genome Database

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The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.

Authors: Liu, Su  Wu, Han-Jun  Zhang, Zong-Qi  Chen, Qing  Liu, Bin  Wu, Jian-Ping  Zhu, Liang 
Citation: Liu S, etal., Eur J Pharmacol. 2011 Jan 10;650(1):384-9. doi: 10.1016/j.ejphar.2010.09.082. Epub 2010 Oct 20.
RGD ID: 25440494
Pubmed: PMID:20965162   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2010.09.082   (Journal Full-text)

Although nonalcoholic steatohepatitis (NASH) is associated with insulin resistance partly due to reduced levels of circulating adiponectin, the role of adiponectin receptors including adiponectin receptor 1 and adiponectin receptor 2 in adipose tissues in NASH remains controversial. The present study showed that there was a marked decline in adiponectin receptor 1 and adiponectin receptor 2 expressions in liver and visceral fat, and these expressions were elevated in muscle of NASH rats 12weeks after oral administration of a high-fat diet. An 8-week continuous treatment with rosiglitazone, a peroxisome proliferator-activated receptors γ (PPAR γ) agonist improved the histological lesions markedly in liver of NASH rats, and concurrently increased mRNA and protein expressions of adiponectin receptor 1 and adiponectin receptor 2 in liver and visceral fat, with down-regulation of the two receptors in muscle. There was a negative correlation between the ratio of adiponectin receptors/β-actin protein and serum TNF-α in the liver and visceral fat, and a positive correlation in muscle. Additionally, rosiglitazone increased circulating adiponectin, which was negatively correlated with serum TNF-α. These results indicated that rosiglitazone improved NASH by directly modulating adiponectin receptor 1 and adiponectin receptor 2 in various adipose tissues, or indirectly possibly via decreasing serum TNF-α.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
metabolic dysfunction-associated steatohepatitis treatmentISOAdipor2 (Rattus norvegicus)25440494; 25440494 RGD 
metabolic dysfunction-associated steatohepatitis treatmentIEP 25440494 RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rosiglitazone affects expression ISOAdipor2 (Rattus norvegicus)25440494; 25440494rosiglitazone affects expression of adipor2 mRNA and protein in NASH (rat) liver more ...RGD 
rosiglitazone affects expression EXP 25440494rosiglitazone affects expression of adipor2 mRNA and protein in NASH (rat) liver more ...RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient levels  IEP 25440494 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOR2  (adiponectin receptor 2)


Additional Information