RGD Reference Report - MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. - Rat Genome Database

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MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2.

Authors: Xu, Meng  Zuo, Dongmei  Liu, Xingxing  Fan, Heng  Chen, Qianyun  Deng, Shuangjiao  Shou, Zhexing  Tang, Qing  Yang, Jia  Nan, Zhen  Wu, Hui  Dong, Yalan  Liu, Yujin 
Citation: Xu M, etal., Biochem Biophys Res Commun. 2017 Jun 17;488(1):6-14. doi: 10.1016/j.bbrc.2017.04.143. Epub 2017 Apr 28.
RGD ID: 25314295
Pubmed: PMID:28461115   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2017.04.143   (Journal Full-text)

MicroRNAs (miRNAs) play an important role in regulating immune system function by mRNA destabilisation or inhibition of translation. Recently, miR-155 was detected to be significantly up-regulated in colonic tissues of patients with active UC. However, it is unknown whether miR-155 is involved in the pathogenesis of UC and how it influences immune response in dextran sulfate sodium (DSS)-induced colitis mice. Here, we investigated the role of miR-155 in UC. Firstly, through bioinformatics analysis and luciferase report assay, we found Jarid2 was a direct target of miR-155; then, we carried out in situ hybridization, immunofluorescence and flow cytometry, and revealed that miR-155 levels were increased, Jarid2 levels were decreased and the frequency of Th17 cells was elevated in DSS-induced mice; we also used lentiviral vector to deliver miR-155 inhibition sequences to silence miR-155 that was effectively taken up by epithelial cells. MiR-155 inhibition attenuated DSS-induced colonic damage and inhibited Th17 cells differentiation. This study suggests that miR-155 plays a host-damaging role during DSS-induced colitis mice and induces Th17 differentiation by targeting Jarid2.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Colitis treatmentISOMir155 (Mus musculus)25314295; 25314295 RGD 
Experimental Colitis treatmentIEP 25314295 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir155  (microRNA 155)

Genes (Mus musculus)
Mir155  (microRNA 155)

Genes (Homo sapiens)
MIR155  (microRNA 155)


Additional Information