RGD Reference Report - Alpha-tocopherol affects androgen metabolism in male rat. - Rat Genome Database

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Alpha-tocopherol affects androgen metabolism in male rat.

Authors: Barella, L  Rota, C  Stocklin, E  Rimbach, G 
Citation: Barella L, etal., Ann N Y Acad Sci. 2004 Dec;1031:334-6.
RGD ID: 2326153
Pubmed: PMID:15753162   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1331.036   (Journal Full-text)

The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study has provided the first evidence implicating vitamin E in hormone synthesis. The effect of vitamin E on stereoidogenesis in testes and adrenal glands was assessed in growing rats using Affymetrix gene-chip technology. Dietary supplementation of rats with vitamin E (60 mg/kg feed) for a period of 429 days caused a significant repression of genes encoding for proteins centrally involved in the uptake (low-density lipoprotein receptor) and de novo synthesis (for example, 7-dehydrocholesterol reductase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, isopentenyl-diphosphate delta-isomerase, and farnesyl pyrophosphate synthetase) of cholesterol, the precursor of all steroid hormones. The present investigation indicates that dietary vitamin E may induce changes in stereoidogenesis by affecting cholesterol homeostasis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to vitamin E  IEP 2326153 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmgcs1  (3-hydroxy-3-methylglutaryl-CoA synthase 1)


Additional Information