RGD Reference Report - An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas. - Rat Genome Database

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An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.

Authors: Fukamachi, K  Tanaka, H  Hagiwara, Y  Ohara, H  Joh, T  Iigo, M  Alexander, DB  Xu, J  Long, N  Takigahira, M  Yanagihara, K  Hino, O  Saito, I  Tsuda, H 
Citation: Fukamachi K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):636-41. Epub 2009 Oct 8.
RGD ID: 2326055
Pubmed: PMID:19818733   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2009.10.019   (Journal Full-text)

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease, which is usually diagnosed in an advanced stage. Animal PDA models which reflect the human condition are clearly necessary to develop early diagnostic tools and explore new therapeutic approaches. We have established transgenic rats carrying a mutated H- or K-ras gene (Hras250 and Kras327) controlled by Cre/loxP activation. These animals develop PDA which are histopathologically similar to that in humans. We utilized this model to identify biomarkers to detect early PDA. We report here that serum levels of Erc/Mesothelin are significantly higher in rats bearing PDA than in controls. Importantly, the levels are significantly elevated in rats before grossly visible carcinomas develop. Even in rats with very small microscopic ductal carcinoma lesions, elevated serum Erc/Mesothelin can be detected. We believe this is the first report of a pancreas tumor animal model in which pre-symptomatic lesions can be diagnosed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal carcinoma disease_progressionIEP 2326055protein:increased secretion:serumRGD 
pancreatic ductal carcinoma disease_progressionISOMSLN (Homo sapiens)2326055; 2326055protein:increased secretion:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Msln  (mesothelin)

Genes (Mus musculus)
Msln  (mesothelin)

Genes (Homo sapiens)
MSLN  (mesothelin)


Additional Information