RGD Reference Report - Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. - Rat Genome Database

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Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.

Authors: Wood, LD  Calhoun, ES  Silliman, N  Ptak, J  Szabo, S  Powell, SM  Riggins, GJ  Wang, TL  Yan, H  Gazdar, A  Kern, SE  Pennacchio, L  Kinzler, KW  Vogelstein, B  Velculescu, VE 
Citation: Wood LD, etal., Hum Mutat. 2006 Oct;27(10):1060-1.
RGD ID: 2325656
Pubmed: PMID:16941478   (View Abstract at PubMed)
DOI: DOI:10.1002/humu.9452   (Journal Full-text)

Tyrosine kinases are major regulators of signal transduction cascades involved in cellular proliferation and have important roles in tumorigenesis. We have recently analyzed the tyrosine kinase gene family for alterations in human colorectal cancers and identified somatic mutations in seven members of this gene family. In this study we have used high-throughput sequencing approaches to further evaluate this subset of genes for genetic alterations in other human tumors. We identified somatic mutations in GUCY2F, EPHA3, and NTRK3 in breast, lung, and pancreatic cancers. Our results implicate these tyrosine kinase genes in the pathogenesis of other tumor types and suggest that they may be useful targets for diagnostic and therapeutic intervention in selected patients.

Objects referenced in this article
Gene NTRK3 neurotrophic receptor tyrosine kinase 3 Homo sapiens
Gene Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 Mus musculus
Gene Ntrk3 neurotrophic receptor tyrosine kinase 3 Rattus norvegicus

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