RGD Reference Report - Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat. - Rat Genome Database

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Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat.

Authors: Roskoden, T  Otten, U  Schwegler, H 
Citation: Roskoden T, etal., Exp Brain Res. 2004 Jan;154(2):183-91. Epub 2003 Oct 14.
RGD ID: 2325630
Pubmed: PMID:14557907   (View Abstract at PubMed)
DOI: DOI:10.1007/s00221-003-1656-5   (Journal Full-text)

The principal glucocorticoid in rats, corticosterone, interacts with neurons in the limbic system and leads to morphological and behavioral changes. Putative corticosterone-triggered mediators are neurotrophins. In the present study we investigated the effects of early postnatal corticosterone treatment in rats on neurotrophic factors of the nerve growth factor (NGF) family and their receptors. Newborn rats were treated with corticosterone-containing polymers until postnatal day 12. The mRNA and protein levels of the neurotrophins of the NGF family (NGF, BDNF, NT-3 and NT-4/5) and their receptors (trkA, trkB, trkC and p75) were quantified in septum and hippocampus using RT-PCR. In the septal region, we found an unchanged mRNA expression after corticosterone treatment, whereas in the hippocampus there was a general increase in mRNA. Particularly, the gene expression of NGF, NT-3, and the high affinity receptors trkA, trkB and trkC increased significantly. Quantification of the neurotrophin protein levels using an ELISA revealed significant treatment effects for NGF and NT-4/5 in the hippocampus. The present study of corticosterone treatment in young rats demonstrates interactions of steroid hormones with neurotrophic factors and their receptors in the septo-hippocampal system during the first two postnatal weeks.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ntrk3Ratresponse to corticosterone  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)


Additional Information