RGD Reference Report - Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.

Authors: Moqrich, A  Earley, TJ  Watson, J  Andahazy, M  Backus, C  Martin-Zanca, D  Wright, DE  Reichardt, LF  Patapoutian, A 
Citation: Moqrich A, etal., Nat Neurosci. 2004 Aug;7(8):812-8. Epub 2004 Jul 11.
RGD ID: 2325628
Pubmed: PMID:15247919   (View Abstract at PubMed)
PMCID: PMC2693051   (View Article at PubMed Central)
DOI: DOI:10.1038/nn1283   (Journal Full-text)

Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons: TrkA is expressed in neurons that sense temperature and noxious stimuli, and TrkC is expressed in proprioceptive neurons that sense body position. Neurotrophin signaling through these receptors is required for cell survival. To test whether neurotrophins have an instructive role in sensory specification, we expressed rat TrkC from the TrkA (also known as Ntrk1) locus in mice. The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ntrk3Ratneuron fate specification  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)


Additional Information