RGD Reference Report - The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. - Rat Genome Database

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The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues.

Authors: Bartman, AE  Buisine, MP  Aubert, JP  Niehans, GA  Toribara, NW  Kim, YS  Kelly, EJ  Crabtree, JE  Ho, SB 
Citation: Bartman AE, etal., J Pathol. 1998 Dec;186(4):398-405.
RGD ID: 2325167
Pubmed: PMID:10209489   (View Abstract at PubMed)
DOI: DOI:10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X   (Journal Full-text)

Secretory mucins play an important role in the cytoprotection of epithelial surfaces and are used as tumour markers in a variety of cancers. The MUC6 secretory mucin was originally isolated from a gastric cDNA library. The aim was to determine the specific type and location of MUC6 mucin gene expression in a wide range of human adult and fetal epithelial tissues. In situ hybridization, RNA analysis, and immunohistochemistry were used to quantify and localize mucin gene expression. The data obtained show that MUC6 is highly expressed in gastric mucosa, duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct; focal expression is seen in basal endometrial and endocervical glands. MUC6 epitopes were also highly expressed in 7/10 pancreatic cancers and 7/10 cholangiocarcinomas and focally expressed in 4/10 endocervical adenocarcinomas. Expression of MUC6 occurs early in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks' gestation. The tissue distribution of the MUC6 secretory mucin indicates that it may function to protect epithelial tissues from a wide range of substances. Expression of MUC6 is frequently preserved in pancreatic and bile duct adenocarcinomas, but it is only sparsely expressed in endocervical carcinomas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholangiocarcinoma  IEP 2325167protein:increased expression: :RGD 
cholangiocarcinoma  ISOMUC6 (Homo sapiens)2325167; 2325167protein:increased expression: :RGD 
pancreatic cancer  IEP 2325167protein:increased expression: :RGD 
pancreatic cancer  ISOMUC6 (Homo sapiens)2325167; 2325167protein:increased expression: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc6  (mucin 6, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc6  (mucin 6, gastric)

Genes (Homo sapiens)
MUC6  (mucin 6, oligomeric mucus/gel-forming)


Additional Information