RGD Reference Report - PPARdelta activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. - Rat Genome Database

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PPARdelta activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation.

Authors: Jiang, YJ  Barish, G  Lu, B  Evans, RM  Crumrine, D  Schmuth, M  Elias, PM  Feingold, KR 
Citation: Jiang YJ, etal., J Invest Dermatol. 2010 Feb;130(2):511-9. Epub 2009 Aug 13.
RGD ID: 2324879
Pubmed: PMID:19675577   (View Abstract at PubMed)
DOI: DOI:10.1038/jid.2009.245   (Journal Full-text)

The goal of epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal permeability barrier function. The regulation of epidermal ontogenesis is poorly understood, but nuclear hormone receptors have been shown to have an important function. As peroxisome proliferator-activated receptor-delta (PPARdelta) is very abundant in fetal epidermis and PPARdelta activation stimulates differentiation and permeability barrier formation in adults, we hypothesized that PPARdelta might regulate epidermal ontogenesis. Treatment of fetal rat explants with the PPARdelta ligand, GW 610742X, accelerates permeability barrier development, evidenced by a decrease in transepidermal water loss and an enhanced outside-in barrier function, attributable to the presence of more mature lamellar membranes in the SC and enhanced expression of loricrin and involucrin. Similarly, the intra-amniotic administration of GW 610742X also accelerates the formation of the SC and permeability barrier development. Finally, in PPARdelta-deficient mice the formation of the SC and the expression of differentiation-related proteins were delayed on days 16.5 and 17.5 of gestation. However, at later stages (day 18.5 and after birth), there were no differences between wild-type- and PPARdelta-deficient mice, indicating only a transient delay in epidermal ontogenesis. These studies show that PPARdelta has a role in SC formation and permeability barrier development.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PpardRatpositive regulation of epidermis development  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppard  (peroxisome proliferator-activated receptor delta)


Additional Information