RGD Reference Report - Genetic analysis of modifiers for the hooded phenotype in the rat. - Rat Genome Database

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Genetic analysis of modifiers for the hooded phenotype in the rat.

Authors: Torigoe, D  Asano, A  Yamauchi, H  Ruiha, D  Sasaki, N  Agui, T 
Citation: Torigoe D, etal., Jpn J Vet Res. 2010 Feb;57(4):175-84.
RGD ID: 2317982
Pubmed: (View Article at PubMed) PMID:20364790

The hooded phenotype is one of the coat color phenotype seen peculiarly in the rat. The hooded locus showing autosomal recessive inheritance is mapped to chromosome (Chr) 14 and that the hooded phenotype receives modification by hooded-modifier gene showing the linkage to the hooded locus. However, a gene responsible for either the hooded or hooded-modifier gene is not yet identified. To clarify genetic control of hooded phenotype, we carried out genetic linkage studies using BN and LEA rats. For determination of phenotypic variation, we measured ratio of pigmented coat area in parental and their F1 and F2 rats. We, then, conducted a genome-wide scan on 152 F2 rats for linkage with ratio of pigmented coat area for the dorsal, ventral, and total regions. A major quantitative trait locus (QTL), D14Got40, showing highly significant linkage contributing 70-90% of the variance for hooded phenotype was detected on Chr 14, which may be correspondent to the hooded locus. In addition, another QTL, D17Rat2, showing highly significant linkage was also detected on Chr 17 in dorsal region phenotype as well as a QTL showing suggestive linkage on Chr15 in ventral region phenotype. We, further, investigated a genome-wide scan for epistatic interactions and detected significant interactions between D14Got40 and D20Mit1, and between D14Got40 and D17Rat2 in the dorsal region phenotype. These results suggest that a major QTL in Chr 14, which is possibly correspondent to the hooded locus, mainly regulates the hooded phenotype with some modifier loci, two of which show epistatic interactions with the hooded locus.

Annotation

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

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Objects Annotated

QTLs
Coatc2  (Coat color QTL 2)
Coatc3  (Coat color QTL 3)
Coatc4  (Coat color QTL 4)
Coatc5  (Coat color QTL 5)

Objects referenced in this article
Strain BN/SsNSlc null Rattus norvegicus
Strain LEA/Tj null Rattus norvegicus

Additional Information