RGD Reference Report - A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. - Rat Genome Database

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A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines.

Authors: Radcliffe, RA  Erwin, VG  Bludeau, P  Deng, X  Fay, T  Floyd, KL  Deitrich, RA 
Citation: Radcliffe RA, etal., Genes Brain Behav. 2009 May 25.
RGD ID: 2317807
Pubmed: PMID:19500156   (View Abstract at PubMed)
PMCID: PMC2880637   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1601-183X.2009.00496.x   (Journal Full-text)

The Alcohol Tolerant and Alcohol Non-Tolerant rats (AT, ANT) were selectively bred for ethanol-induced ataxia as measured on the inclined plane. Here we report on a quantitative trait locus (QTL) study in an F(2) intercross population derived from inbred AT and ANT (IAT, IANT) and a follow-up study of congenics that were bred to examine one of the mapped QTLs. Over 1200 F(2) offspring were tested for inclined plane sensitivity, acute tolerance on the inclined plane, duration of the loss of righting reflex (LORR) and blood ethanol at regain of the righting reflex (BECRR). F(2) rats that were in the upper and lower 20% for inclined plane sensitivity were genotyped with 78 SSLP markers. Significant QTLs for inclined plane sensitivity were mapped on chromosomes 8 and 20; suggestive QTLs were mapped on chromosomes 1, 2 and 3. Highly significant QTLs for LORR duration (LOD = 12.4) and BECRR (LOD = 5.7) were mapped to the same locus on chromosome 1. Breeding and testing of reciprocal congenic lines confirmed the chromosome 1 LORR/BECRR QTL. A series of recombinant congenic sub-lines were bred to fine-map this QTL. Current results have narrowed the QTL to an interval of between 5 and 20 Mb. We expect to be able to narrow the interval to less than 5 Mb with additional genotyping and continued breeding of recombinant sub-congenic lines.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AT.ANT-(D1Rat158-D1Rat288)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat183-D1Rat288)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat234-D1Rat158)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat234-D1Rat35)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat234-D1Rat38)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat234-D1Rat47)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat273-D1Rat158)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat273-D1Rat288)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat35-D1Rat288)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat35-D1Rat38)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat35-D1Rat47)/RarRatalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Uia12-D1Rat288)/RarRatalcohol-induced mental disorder  IAGP  RGD 
Alcrsp19Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp20Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp21Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp22Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp23Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp24Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp25Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp26Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp27Ratalcohol-induced mental disorder  IAGP  RGD 
Alcrsp28Ratalcohol-induced mental disorder  IAGP  RGD 
AT.ANT-(D1Rat158-D1Rat288)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat183-D1Rat288)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat158)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat35)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat38)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat47)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat273-D1Rat158)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat273-D1Rat288)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat288)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat38)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat47)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Uia12-D1Rat288)/RarRatAtaxia MODEL: inducedIAGP alcoholRGD 
Alcrsp1RatAtaxia  IAGP alcoholRGD 
Alcrsp19RatAtaxia  IAGP alcoholRGD 
Alcrsp20RatAtaxia  IAGP alcoholRGD 
Alcrsp21RatAtaxia  IAGP alcoholRGD 
Alcrsp22RatAtaxia  IAGP alcoholRGD 
Alcrsp23RatAtaxia  IAGP alcoholRGD 
Alcrsp24RatAtaxia  IAGP alcoholRGD 
Alcrsp25RatAtaxia  IAGP alcoholRGD 
Alcrsp26RatAtaxia  IAGP alcoholRGD 
Alcrsp27RatAtaxia  IAGP alcoholRGD 
Alcrsp28RatAtaxia  IAGP alcoholRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AT.ANT-(D1Rat158-D1Rat288)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat183-D1Rat288)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat158)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat35)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat38)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat234-D1Rat47)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat273-D1Rat158)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat273-D1Rat288)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat288)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat38)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Rat35-D1Rat47)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
AT.ANT-(D1Uia12-D1Rat288)/RarRatabnormal motor coordination/balance MODEL: inducedIAGP alcoholRGD 
Alcrsp19Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp20Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp21Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp22Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp23Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp24Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp25Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp26Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp27Ratabnormal motor coordination/balance  IDA alcoholRGD 
Alcrsp28Ratabnormal motor coordination/balance  IDA alcoholRGD 
AT.ANT-(D1Rat158-D1Rat288)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat183-D1Rat288)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat234-D1Rat158)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat234-D1Rat35)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat234-D1Rat38)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat234-D1Rat47)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat273-D1Rat158)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat35-D1Rat288)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat35-D1Rat38)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Rat35-D1Rat47)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
AT.ANT-(D1Uia12-D1Rat288)/RarRatalcohol preference MODEL: inducedIAGP  RGD 
Alcrsp19Ratalcohol preference  IDA  RGD 
Alcrsp20Ratalcohol preference  IDA  RGD 
Alcrsp21Ratalcohol preference  IDA  RGD 
Alcrsp22Ratalcohol preference  IDA  RGD 
Alcrsp23Ratalcohol preference  IDA  RGD 
Alcrsp24Ratalcohol preference  IDA  RGD 
Alcrsp25Ratalcohol preference  IDA  RGD 
Alcrsp26Ratalcohol preference  IDA  RGD 
Alcrsp27Ratalcohol preference  IDA  RGD 
Alcrsp28Ratalcohol preference  IDA  RGD 
Alcrsp19Ratimpaired righting response  IDA alcoholRGD 
Alcrsp22Ratimpaired righting response  IDA alcoholRGD 
Alcrsp27Ratimpaired righting response  IDA alcoholRGD 
Objects Annotated

QTLs
Alcrsp1  (Alcohol response QTL 1)
Alcrsp19  (Alcohol response QTL 19)
Alcrsp20  (Alcohol response QTL 20)
Alcrsp21  (Alcohol response QTL 21)
Alcrsp22  (Alcohol response QTL 22)
Alcrsp23  (Alcohol response QTL 23)
Alcrsp24  (Alcohol response QTL 24)
Alcrsp25  (Alcohol response QTL 25)
Alcrsp26  (Alcohol response QTL 26)
Alcrsp27  (Alcohol response QTL 27)
Alcrsp28  (Alcohol response QTL 28)


Additional Information