RGD Reference Report - A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. - Rat Genome Database

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A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines.

Authors: Radcliffe, RA  Erwin, VG  Bludeau, P  Deng, X  Fay, T  Floyd, KL  Deitrich, RA 
Citation: Radcliffe RA, etal., Genes Brain Behav. 2009 May 25.
RGD ID: 2317807
Pubmed: (View Article at PubMed) PMID:19500156
DOI: Full-text: DOI:10.1111/j.1601-183X.2009.00496.x

The Alcohol Tolerant and Alcohol Non-Tolerant rats (AT, ANT) were selectively bred for ethanol-induced ataxia as measured on the inclined plane. Here we report on a quantitative trait locus (QTL) study in an F(2) intercross population derived from inbred AT and ANT (IAT, IANT) and a follow-up study of congenics that were bred to examine one of the mapped QTLs. Over 1200 F(2) offspring were tested for inclined plane sensitivity, acute tolerance on the inclined plane, duration of the loss of righting reflex (LORR) and blood ethanol at regain of the righting reflex (BECRR). F(2) rats that were in the upper and lower 20% for inclined plane sensitivity were genotyped with 78 SSLP markers. Significant QTLs for inclined plane sensitivity were mapped on chromosomes 8 and 20; suggestive QTLs were mapped on chromosomes 1, 2 and 3. Highly significant QTLs for LORR duration (LOD = 12.4) and BECRR (LOD = 5.7) were mapped to the same locus on chromosome 1. Breeding and testing of reciprocal congenic lines confirmed the chromosome 1 LORR/BECRR QTL. A series of recombinant congenic sub-lines were bred to fine-map this QTL. Current results have narrowed the QTL to an interval of between 5 and 20 Mb. We expect to be able to narrow the interval to less than 5 Mb with additional genotyping and continued breeding of recombinant sub-congenic lines.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Alcrsp1  (Alcohol response QTL 1)
Alcrsp19  (Alcohol response QTL 19)
Alcrsp20  (Alcohol response QTL 20)
Alcrsp21  (Alcohol response QTL 21)
Alcrsp22  (Alcohol response QTL 22)
Alcrsp23  (Alcohol response QTL 23)
Alcrsp24  (Alcohol response QTL 24)
Alcrsp25  (Alcohol response QTL 25)
Alcrsp26  (Alcohol response QTL 26)
Alcrsp27  (Alcohol response QTL 27)
Alcrsp28  (Alcohol response QTL 28)

Objects referenced in this article
Strain ANT Alcohol-Nontolerant Rattus norvegicus
Strain AT Alcohol-Tolerant Rattus norvegicus

Additional Information