RGD Reference Report - DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate. - Rat Genome Database

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DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate.

Authors: Crespi, MD  Radicella, JP  Baldi, A  Charreau, EH  Calvo, JC 
Citation: Crespi MD, etal., Mol Cell Endocrinol. 1987 Oct;53(3):221-6.
RGD ID: 2317068
Pubmed: PMID:2822514   (View Abstract at PubMed)

The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Top1Ratcellular response to luteinizing hormone stimulus  IEP  RGD 
Top1Ratresponse to cAMP  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Top1  (DNA topoisomerase I)


Additional Information